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Caramori G, Casolari P, Barczyk A, Durham AL, Di Stefano A, Adcock I

doi: 10.3389/fphar.2024.1396231 Received 05 March 2024 Accepted 02 July 2024 Published 18 July 2024 Volume 15 - 2024 Edited by Nunziatina De Tommasi, University of Salerno, Italy Reviewed by Ang Luo, Northwest A&F University, China Roberto V

The P9 Protein: A Microbial Signal to the Gut In mouse and cell studies, researchers found that Akkermansia secretes a protein called P9, which binds to a receptor (ICAM-2) on gut cells and triggers GLP-1 release, and in mice it also raised energy expenditure (Yoon et al., 2021)

The flow rate was kept at 300 l min 1 and gradient was as follows: 0 min 80% of B, 12 min 50% of B, 26 min 50% of B, 28 min 20% of B, 36 min 20% of B, 3745 min 80% of B