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Neprilysin inhibition in heart failure: Mechanisms and substrates beyond modulating natriuretic peptides

Research shows that GLP-1 medications like semaglutide can lead to dramatic early weight loss, but plateaus typically occur after several months, requiring a new, physician-guided approach for continued success

Accumulation of these metabolites and their breakdown products in patients with CKD may be associated with the development of neurotoxicity and uremic breath. 481,487,492