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This reaction results in the formation of hydroperoxides, which can then be further metabolized into a variety of bioactive molecules, including leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and fatty acid epoxides [246]

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The fact that this MIC far exceeds the clinical breakpoint by several-fold to tens of folds strongly suggests that the bacterium likely produces drug-inactivating enzymes, such as aminoglycoside-modifying enzymes, which efficiently destroy antibiotic molecules, leading to high-level resistance

12 Protein subcellular localization The subcellular localization of proteins is intricately associated with lactylation, which affects their distribution and biological functions