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On the other hand, DPP-4, the incretin degrading endopeptidase, has been found to be reduced in tissue and plasma in active CD (170) and further inhibition of DPP-4 accelerated mucosal healing in a murine model of colitis (171)

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That lineage now includes Ozempic, Mounjaro, and a growing roster of treatments that have not only changed the lives of patients with diabetes and obesity but also ushered in the cultural phenomenon of peptides