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Mice were anaesthetized using sodium pentobarbital at a dose of 180 mg kg 1 (Dolethal, Vetoquinone)

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R285C) as having strong correlations with serum creatinine levels (HuGE score, 121800) and estimated glomerular filtration rate (eGRF) for creatinine (HuGE score, 350) ( Supplementary Fig.1B )

Oxidative stress can lead to carcinogenesis through its ability to alter genetic material (DNA), affect cellular signalling pathways and cell cycle regulation, promote angiogenesis and metastasis