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Clinical Eligibility and Medical Evaluation on Hers Hers typically requires patients to meet standard GLP-1 criteria: BMI 30 or 27 with weight-related comorbidities, stable cardiovascular health, no personal or family history of medullary thyroid carcinoma, and adequate renal function

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As far as possible, doses of basal insulin and metformin were to remain stable throughout the trial, with the exception of (1) dose reduction due to hypoglycemia or (2) confirmatory fasting plasma glucose (FPG) exceeding predefined limits per protocol, where the patient was offered intensification of therapy (rescue medication)