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"In cases where glutathione demands are high, or there are genetics inhibit glutathione production, glutathione supplementation is often very effective." Taking glutathione itself is problematic because it is a peptide, and peptides break down in the digestive system

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Abbreviations CK: Creatine kinase DIP: l-alanyl-l-glutamine GABA: -Aminobutyrate GSH: Glutathione HSE: Heat shock element HSF: Heat shock factor HSP: Heat shock proteins HSP70: 70-kDa protein family IL: Interleukin LDH: Lactate dehydrogenase LIF: Leukaemia inhibitory factor MCP: Monocyte chemotactic protein MDC: Chemokine derived from macrophage PepT: Intestinal transporter ROS: Reactive oxygen species SLC: Solute carrier TNF: Tumour necrosis factor uPA: Fractalkine and urokinase plasminogen activator VEGF: Vascular endothelial growth factor References Newsholme P, Procopio J, Lima MM, Pithon-Curi TC, Curi R

Deficiencyreduces T3 levels causing classichypothyroidism symptoms such as fatigue,depression and/or weight gain