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Una vez dentro de la mitocondria, la Acilcarnitina regenera el Acil-coA y libera a los cidos grasos que entrarn en el ciclo de la Betaoxidacion desde donde se generan molculas de ACetil CoA que entran al ciclo de Krebs para generar hidrgenos y electrones de la misma manera que el acetil CoA derivado desde la glucosa (Manore & Thompson 2000)

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Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression