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It also altered immune mediatorsupregulating Cxcl2 and Il-6 while suppressing Ifn- and Tgf- thereby disturbing mucosal homeostasis through concurrent shifts in microbiota, mucus composition, and cytokine signaling (Fig

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Not only does having a mental health or substance use challenge make a person more at risk for using tobacco, but using tobacco increases the likelihood of using other substances, according to the New England Journal of Medicine