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Potential warning signs include: Noticeable weakness Loss of muscle tone Dizziness Persistent fatigue Hair shedding Feeling cold all the time Constipation Poor workout recovery Low protein intake Very low appetite Reduced balance or stamina Rapid weight loss without strength training These symptoms do not always mean muscle loss is occurring, but they should prompt a conversation with a qualified medical provider

Increasing intracellular iron levels enhances Fenton chemistry and ROS generation, whereas targeted iron delivery systems (e.g., iron oxide nanoparticles) can selectively amplify oxidative stress within tumours (99, 100)

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S1 nerve compression causes pain down the back of the leg to the heel, with potential weakness in plantar flexion (pushing off with the toes)