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When levels drop, the effects show up in ways that feel vague and hard to pin down

These include alterations in the monoaminergic system, changes in glutamatergic synaptic transmission, neuro-inflammation, alterations in the hypothalamic-pituitary-adrenocortical (HPA) axis, changes in brain-derived neurotrophic factor (BDNF), and hippocampal atrophy ( However, depression in AD is more specifically linked to deficits in certain brain regions and AD-related pathological changes

4 shows the marked associations between contaminants and cord serum metabolic profiles along with demographic variables