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Its molecular formula is CHNO , and it operates as an agonist at melanocortin receptors primarily MC3R and MC4R which are expressed throughout the hypothalamus, the brain region governing sexual behavior, appetite, and energy homeostasis

In July 2021, the FDA issued Ardelyx a Complete Response Letter in which it stated that the molecules effect size was small and of unclear clinical significance. Then, in November 2022, an FDA advisory committee voted 9-4 that Xphozahs benefits outweighed its risks

These products are sold labeled as "for research purposes only," which is a legal workaround that allows suppliers to avoid pharmaceutical regulations