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PROPHYLOCHIP-PRODIGE 15 tested the efficacy of cytoreductive surgery and HIPEC (predominantly oxaliplatin) administered after six months of adjuvant systemic chemotherapy to colorectal cancer cases with synchronous and localized peritoneal metastases, removed with the primary tumor, with perforated primary tumor or with resected ovarian metastases free of recurrence, which failed to achieve superior results to cytoreductive surgery and adjuvant systemic chemotherapy [181]

Side effects are generally mild to moderate and diminish as your body adjusts during dose escalation

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