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Additional mast cell-derived biochemical markers that can be used for diagnosis include: Histamine Histamine metabolites PGD 2 metabolites Heparin Symptom improvement: Consensus-2 also includes a measurable response and improvement of symptoms when administered the following drug therapies: Mast cell-stabilizing agents Drugs directed against mast cell mediator production Drugs blocking mediator release or effects of mast cell-derived mediators Having broader and more robust diagnostic guidelines as seen in the updated consensus-2 criteria allows us to more accurately diagnose patients