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Additional analyses may include assessment of peptide stability under varying storage conditions, structural integrity following reconstitution, mapping of interaction patterns within IGF-associated pathways, and observation of downstream intracellular signaling responses within regulated in vitro and preclinical experimental systems

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A recent study showed that alleviating ganglioside accumulation can significantly reduce the number of neuron deaths and thus improve the disease phenotype in zebrafish models with the SPG11 mutation 124