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The accumulation of 2-HG triggers the inhibition of -KG-dependent enzymes, such as TET2 (Tet methylcytosine dioxygenase 2) demethylase, and consequently alters gene expression by favoring DNA hypermethylation (Raimondi et al., 2022)
Despite these caveats, consuming bone broth falls into the cant-hurt-and-might-help category
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We hope this review will serve as a valuable resource for understanding the significance of MTHFR polymorphisms and their complex relationships with various diseases
