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doi: 10.1007/BF03346639

It also has anti-inflammatory effects, decreasing the pro-inflammatory cytokines TNF-, IL-6, MCP-1 and IL-1 in serum and liver, and inhibiting the TLR4/NFkB pathway

Tirzepatide (Zepbound) - FDA Approved 2023: According to clinical trials cited by multiple sources including NBC News, tirzepatide (a GIP/GLP-1 dual agonist) showed approximately 21% to 22.5% mean weight loss on its highest dose after 72 weeks, compared to approximately 3% for placebo