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It is also a cautionary illustration of how much context a mechanism carries: the best-characterized KPV effect depends on an intestinal transporter (PepT1) abundant in gut epithelium, which is one reason KPV has been explored mainly for oral delivery in bowel inflammation rather than as a general-purpose systemic anti-inflammatory

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This approach helps maintain endocrine balance instead of bypassing regulatory systems

Some people may also notice mild peeling or dryness as the skin heals, which is completely normal