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Illuminating an invisible epidemic: a systemic review of the clinical and economic benefits of early diagnosis and treatment in inflammatory disease and related syndromes

Certainly, untargeted metabolomics would be useful in ruling out IEMs, but whether or not this kind of testing would be most appropriate incorporated into newborn screening programs versus primarily used for confirmation of a clinical diagnosis remains to be seen (169, 170)

In vitro and in vivo studies demonstrate an IGF-1 deficiency can deregulate lipid metabolism, increase the risk of cardiovascular disease, and compromise the metabolic profile of diabetic patients

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