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(D) Western blots were performed, and (E) the relative protein levels of Sp1, SIRT1, acetyl-HIF-1, HIF-1, p21, and p27 in MLE-12 cells were determined (n = 3)

1 , 2 A slight drop in blood pressure is usually not a significant concern, as vasodilation is a natural physiological process that occurs from time to time

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