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The trial enrolled 281 participants across 42 research and healthcare centers in the United States, randomized to once-weekly subcutaneous retatrutide (0.5, 4, 8, or 12 mg), once-weekly subcutaneous dulaglutide 1.5 mg (active comparator), or placebo, over a 36-week treatment period

There is, however, a limit

You should not use semaglutide if you: Semaglutide may not be safe if you: Are pregnant, planning pregnancy, or breastfeeding Have personal or family history of medullary thyroid cancer Have Multiple Endocrine Neoplasia Syndrome type 2 (MEN2) Have a history of pancreatitis Have experienced serious allergic reactions to semaglutide Have severe kidney or liver disease A licensed provider will review your medical history before prescribing

Carnitine acetyltransferase: the question of multiple forms Eur J Biochem 1974