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Investigators have also noted that the pronounced appetite-stimulating effect of MK-677 an on-target consequence of ghrelin receptor agonism in hypothalamic appetite circuits complicates body composition endpoints in metabolic studies, as caloric intake must be carefully controlled to isolate GH-axis-mediated changes from orexigenic-driven weight gain

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"Stable gastric pentadecapeptide BPC 157: Novel therapy in gastrointestinal tract." Current Pharmaceutical Design , 24(18), 1990-2001