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Now, Winfrey says, just as she takes blood pressure medication to control a disease that runs in her family, she also takes a GLP-1 drug to control her enough point (she has declined to specify which drug she takes, but so far there are only two on the market: semaglutide from Novo Nordisk, and tirzepatide from Eli Lilly)

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GLP-1 receptor agonists enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which normally raises blood sugar), and slow gastric emptying