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Its deficiency causes oxidative stress that not only promotes the oxidation of proteins and deoxyribonucleic acid (DNA) but also leads to insulin resistance, dyslipidemia, inflammation, and metabolic alterations, which expose to high risk for cardiometabolic disorders due to cardiovascular and degenerative diseases especially when associated with aging

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Therefore, we perform a cysteine scan of every amino acid in the structured region of SpyCatcher to identify mutants with lowered activity when modified by disulfide-forming small probes