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Saptawati Bardosono, MSc, a clinical nutrition specialist and a lecturer at the University of Indonesia's School of Medicine, cigarettes contain active substances that contribute to doubling the amount of free radicals in the body, as reported by kompas.com

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Unfortunately, these health advantages are overshadowed when combined with areca nut and tobacco, both established as carcinogenic agents [6]

If a smoker's melanosis is destroyed by excessive smoking, as in the hard palate of reverse smokers, who smoke with the glowing part of the cigarette inside the mouth for different reasons, a pale depigmented surface is first seen, indicating the loss of the protecting melanin