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Kevin Ree, DO, UnityPoint Health Location-Specific Patterns and Significance Cervical (Neck) Lymph Nodes Anterior cervical nodes (front of neck): Most commonly affected by upper respiratory infections Often enlarged with strep throat, viral pharyngitis May indicate dental infections or oral cavity problems Usually tender and mobile when infected Posterior cervical nodes (back of neck): Frequently involved in scalp infections or dermatitis May enlarge with mononucleosis or other systemic viral infections Sometimes associated with rubella or other childhood illnesses Axillary (Armpit) Lymph Nodes Common causes of axillary lymphadenopathy: Upper extremity infections - cuts, scrapes, or cellulitis on arms/hands Breast-related conditions - infections, inflammatory conditions, or malignancy Recent vaccinations - particularly COVID-19 vaccines in the corresponding arm Deodorant reactions - allergic contact dermatitis Inguinal (Groin) Lymph Nodes Typical triggers for inguinal node enlargement: Lower extremity infections - athlete's foot, leg wounds, cellulitis Genital infections - sexually transmitted infections, yeast infections Urinary tract infections - especially recurrent or complicated cases Abdominal infections - appendicitis, diverticulitis, or other inflammatory conditions For expert evaluation of concerning lymph node enlargement, consider consulting with our experienced medical team who specialize in diagnostic assessment