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In humans and rodents, metformin is concentrated in the liver and blocking the uptake of metformin into the liver in mice prevents the ability of metformin to lower blood glucose levels (48,49)

Radiation-induced downregulation of BACH transcriptional regulator 1 (BACH1), a transcriptional repressor of SLC7A11 , further sensitizes cells to cuproptosis 170

The Science GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications originally developed for type 2 diabetes that have transformed medical weight loss

Because it remains an investigational peptide, more research is needed to fully understand its safety and long-term effects