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And they make it easier for people to smoke, said Thomas Novotny, a professor of public health at San Diego State University

Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics

When you buy cigarettes at a store, the retail price includes federal excise duty, provincial tobacco tax, and distribution costs layered on top of the actual tobacco product

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