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However, based on the results of the ordered logistic regression analysis in this study, the role of ferroptosis biomarkers (MDA, GSH) in retinal damage becomes more pronounced as kidney function worsens, particularly in advanced CKD patients

Jeong et al., 2018

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Second, given that the activation of GSR and TXNRD1 are involved in ROS elimination, if the LCS3-triggered lethality of VRK2-KO PC cells could be attributed to inhibiting the activity of both GSR and TXNRD1, then the level of ROS generated by LCS3 should have been much higher than those produced by the treatment of the TXNRD1 inhibitor auranofin