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Molecular modelling and mutagenesis studies indicate that agonist positive allosteric modulators target the same general region, but in a distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupling

doi: 10.1007/s11033-025-10368-8 107

6 Discussion and perspectives This review categorizes anti-osteoporotic natural products into five main groups: flavonoids, glycosides/saponins, phenolics, polysaccharides, and terpenoids