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Wolzt M, MacAllister RJ, Davis D, et al

Advantage: Convenient, familiar, non-invasive Challenge: Peptides face proteolytic degradation in the stomach and small intestine Bioavailability: Estimated at approximately 38% based on comparative pharmacology (see below) Transdermal (Patch) Some researchers have explored transdermal patches to deliver peptides: Advantage: Avoids first-pass metabolism and GI degradation Challenge: Intact skin is a strong barrier to peptide penetration Feasibility: Not commonly available commercially

Skin sensitivity affects daily activities and can cause significant discomfort, making it important to understand its potential triggers

IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times