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It indicates that the synergistic stress of heat and drought causes more significant harm to tobacco compared to individual stressors (Wang et al., 2024)

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After adjustment for age, sex, race and ethnicity, education, and body mass index, primary cigar users (those who smoked less than 100 cigarettes in their lives) had 138 times higher serum cotinine concentrations (6.2 ng/mL versus 0.045 ng/mL) and 18.9 times higher urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) concentrations (19.1 picogram [pg]/mg creatinine versus 1.01 pg/mg creatinine) than nontobacco users