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Chronic low-dose aspirin therapy irreversibly inhibits the cyclooxygenase-1 ( COX-1) activity in platelets, leading to reduced thromboxane A2 production and thereby exerting anti-platelet aggregation effects

A right upper quadrant ultrasound can confirm or exclude this diagnosis

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is important for the synthesis of phospholipids from these PUFAs, while lysophosphatidylcholine acyltransferase 3 (LPCAT3) is important for their insertion into membrane phospholipids (Kagan et al., 2017)

Patients and providers may struggle to distinguish drug-induced nausea from active disease inflammation or gastroparesis