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In both cases, oxidative stress constitutes an important trigger for the emergence of microvascular and macrovascular complications (Fig

These have inspired a striking piece of investigation, as one of the repetitively arranged depressions resembles the substrate-binding site of glutathione peroxidase (GPx, EC 1.11.1.9), a natural selenoenzyme: Computer-aided design identified adjacent, adequately positioned amino acids of the viral CP which offered the chance to be modified into a glutathione-attracting pocket containing a catalytic selenocysteine (Sec) moiety [133]

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