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E2 treatment increases the expression of carnitine palmitoyltransferase I (49), which catalyses the transfer of long-chain fatty acids into the mitochondrial matrix for the rate-limiting step of fatty acid oxidation (59)

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For musculoskeletal indications, the guideline is progressive load reintroduction starting no earlier than 6 to 8 weeks, with full training not before 3 months for significant tendon injuries regardless of how good the patient feels