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Modulation of inflammasome and pyroptosis by olaparib, a PARP-1 inhibitor, in the R6/2 mouse model of Huntingtons disease

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There was a tendency toward higher t 1/2 with increasing hepatic impairment ranging from 174 h (range 144204 h) in the group with normal hepatic function to 199 h (range 184214 h) in the group with severe hepatic impairment