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Why higher doses often work better Higher doses correlate with higher appetite suppression and metabolic effects, leading to a more significant decrease in metabolic markers, such as BMI, waist circumference, and HbA1C

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Nausea is a side effect which affects 3050% of patients taking GLP-1R agonists at clinically licensed doses 15 , with higher doses glycemically more effective but consistently associated with unacceptable tolerability 16,17,18,19