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For instance, (R) naringenin from RD and 24 ethylcholest 22 enol from LF both demonstrated a significant positive modulation of the ESR1 gene ( = 0.429, P = 0.001, OR = 1.536, 95% CI: 1.180-2.000), suggesting that these components might collaboratively participate in the pathophysiology of OP through regulation of the ESR1 gene