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Phase I detoxification enzymes, including several aldo-keto reductase family members ( AKR1C1 , AKR1B1 , and AKR1B10 , which catalyze the conversion of aldehydes and ketones to their corresponding alcohols) and NADPH dehydrogenase quinone 1 ( NQO1 ) (reduces reactive quinone species capable of generating reactive oxygen species [ROS]), are classical NRF2 target genes (54,6971)

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A., Abdel Aal, S

In this regard, we crossed gpx4 fl/fl mice with CD4-cre mice to generate conditional knockout mice with T cellspecific depletion of GPX4 (CD4-cre + gpx4 fl/fl [GPX4 cKO]) for further investigation