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Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

KPV KPV, composed of lysine-proline-valine, is identified as the C-terminal end of the larger alpha-melanocyte-stimulating hormone (-MSH), which is endogenously produced in the body

4 Recently, it has been observed that the human erythrocyte GSTP1-1 (e-GST) is overexpressed in the case of increased blood toxicity as it occurs in healthy subjects living in polluted areas and in nephrologic patients under conservative or dialytic therapies

Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research