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In rare cases, more serious side effects such as pancreatitis, kidney problems, bowel obstruction, or allergic reactions can occur

Acquisition of allelic imbalance and loss of heterozygosity Apparent loss of SNVs and indels can be caused by a number of processes: deletion of one or more copies of an allele including LOH, reversion of mutations, dominance in metastases by sub-clones without mutations, and genetic heterogeneity in antecedent tumours not inherited by later metastases or acquired at the site of origin after dissemination of metastatic cells 29

Regions with secondary structures typically exhibit higher hetNOE values ( 0.6)

Keep servings modest: Typical servings are 515 g/day