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Current guidance from the American Optometric Association outlines potential risks associated with GLP-1 therapies, including diabetic retinopathy progression and rare optic nerve complications, and emphasized the need for baseline exams and ongoing monitoring

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The only FDA-approved oral GLP-1, Rybelsus, required a specialized absorption enhancer called SNAC to achieve roughly 1% bioavailability, and even then must be taken under tightly controlled conditions