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Although various PHGDH inhibitors have been developed (including ketothioamide, BI-4924, indoleamide, piperazine-1-thiourea inhibitors, and allosteric inhibitors) and have demonstrated anti-tumor effects, no PHGDH inhibitors have been approved by the FDA for clinical application, as a result of challenges such as metabolic compensation, drug selectivity, resistance, toxicity, and the complexity of drug development [165, 166]

Roughly 240,000 of these patients will die as

Interestingly, glucose intolerance could be improved when IGF-1 was systemically administered

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