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Other Hangover Causes Include: Inflammatory responses from the immune system Low blood sugar Stomach irritation (gastritis) Depletion of electrolytes Blood vessel expansion (vasodilatation) Chemicals produced by alcohol metabolism Congeners (compounds used as color and flavor enhancers for liquors) Hormonal disruption (serotonin, histamine, and prostaglandins) Sleep interference According to the research, about 75 percent of all who drink an excessive amount of alcohol to the point of being intoxicated experience hangovers