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Compared with case-control studies [39, 40], prospective studies may lose some statistical power, but estimates of the absolute risk support using the PRS to predict incident lung cancer [10, 41]

Health warnings The pack must carry a health warning covering 30% of the surfaces of the unit packet and any outside packaging stating This product contains nicotine which is a highly addictive substance. The Medicines and Healthcare products Regulatory Agency (MHRA) is the competent authority for the notification scheme for e-cigarettes and refill containers in the UK.[27] Consumers and healthcare professionals can report side effects and safety concerns with e-cigarettes or refill containers to the MHRA through the Yellow Card reporting system.[28] They can also report products suspected to be defective or non-compliant to their local Trading Standards service or to [email protected]

Finally, the non-carcinogenic health risk assessment, which addressed the fourth point, indicated that HQ values were greater than 1, confirming a considerable ingestion risk of Pb and Cd for both adults and children

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