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On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure

Safety & Contraindications GLOW and its component peptides are not FDA-approved drugs

high homocysteine levels can be caused by deficiency in folate and/or vitamin B12 (Arzumanyan 2008)

Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide