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J-EG-M declares that he has received honoraria for lectures for AstraZeneca, Bayer, Boheringer Ingelheim, Merck, and Xinetixs Pharma

Early clinical trials in diabetic patients have indicated that GLP-1RAs treatment is associated with improvements in health-related quality of life and well-being compared with insulin and sulfonylureas.174176 A notably comparable study is the population-based cohort analysis by Gamble et al,174 which utilized UK databases to assess the incidence of new-onset depression or self-harm among new users of GLP-1RAs and dipeptidyl peptidase-4 inhibitors relative to sulfonylureas

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