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The monitoring of real-world use patterns is predominantly achieved via national and international health surveillance systems (eg, Behavioral Risk Factor Surveillance System, Global Adult Tobacco Survey, Youth Risk Behavior Surveillance System), along with other large observational studies (eg, US Population Assessment of Tobacco and Health Study, International Tobacco Control Policy Evaluation Project, National Youth Tobacco Survey) that focus on tobacco and/or nicotine use

The oral feel may take some getting used to for new users Effects may be more subtle compared to stimulant-based nicotine products 3

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These analyses are generally aimed at comparing yields of smoke toxicants under a defined set of machine-smoking parameters