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Nicotine pouches do not contain tobacco leaf, although some use plant-derived nicotine

Because vaping don't produce harmful smoke like smoking cigarettes do, some people think it's safe

The only brand of toothpick in this study was Pixotine, a manufacturer of nicotine-infused toothpicks, whose website states that it aimed to offer a solution for smokeless nicotine/tobacco users dealing with hand-to-mouth actions and oral fixations.35 The website indicates that the product consists of nicotine derived from tobacco leaves and is sold in two nicotine strengths: zero nicotine or 3 mg.35 Although advertised as 3 mg per toothpick, the measured total nicotine content was about two times less than labelled, with a mean of 1.33 mg/toothpick (SE=0.85)