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While sub-chronic exposure to PG/nicotine promote nAChR7-dependent increased levels of different cytokines and chemokines in the bronchoalveolar lavage fluid (BALF) such as IL-1, IL-2, IL-9, interferon (IFN), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1/CCL2) and regulated on activation, normal T cell expressed and secreted (RANTES/CCL5), the enhanced levels of IL-1, IL-5 and TNF were nAChR7 independent

The company is leaning further into that momentum, launching a ZYN Ultra range and new flagship dry flavors in June, with additional nicotine-strength variants due in Q3, backed by a new "When it clicks" ad campaign

September 1, 2021

He encourages providers to talk about the subject in a positive way, outlining the health benefits, and look for ways to help a patient quit, whether it be counseling, medication or both